Mouth cancer, also known as oral cancer, is where a tumour develops in a part of the mouth. It may be on the surface of the tongue, the inside of the cheeks, the roof of the mouth (palate), the lips or gums.
Tumours can also develop in the glands that produce saliva, the tonsils at the back of the mouth, and the part of the throat connecting your mouth to your windpipe (pharynx). However, these are less common.
Symptoms of mouth cancer
The symptoms of mouth cancer include:
- mouth ulcers that are painful and do not heal within several weeks
- unexplained, persistent lumps in the mouth or the neck that do not go away
- unexplained loose teeth or sockets that do not heal after extractions
- unexplained, persistent numbness or an odd feeling on the lip or tongue
- sometimes, white or red patches on the lining of the mouth or tongue These can be early signs of cancer, so they should also be checked
- changes in speech, such as a lisp
See a GP or dentist if these symptoms do not get better within 3 weeks, particularly if you drink or smoke.
Find out more about the symptoms of mouth cancer.
Types of mouth cancer
Mouth cancer is categorised by the type of cell the cancer (carcinoma) starts to grow in.
Squamous cell carcinoma is the most common type of mouth cancer, accounting for 9 out of 10 cases.
Squamous cells are found in many areas of the body, including the inside of the mouth and in the skin.
Less common types of mouth cancer include:
- adenocarcinoma, which is cancers that develop inside the salivary glands
- sarcoma, which grows from abnormalities in bone, cartilage, muscle or other tissue
- oral malignant melanoma, where cancer starts in the cells that produce skin pigment or colour (melanocytes). These appear as very dark, mottled swellings that often bleed
- lymphoma, which grows from cells usually found in lymph glands, but they can also grow in the mouth
What causes mouth cancer?
Things that increase your risk of developing mouth cancer include:
Treating mouth cancer
There are three main treatment options for mouth cancer, including:
- surgery to remove the cancerous cells, along with a tiny bit of the surrounding normal tissue or cells to ensure the cancer is completely removed
- radiotherapy – where beams of radiation are directed at the cancerous cells
- chemotherapy – where powerful medicines are used to kill cancerous cells
These treatments are often used in combination. For example, surgery may be followed by a course of radiotherapy to help prevent the cancer returning.
As well as trying to cure mouth cancer, treatment will focus on preserving important functions of the mouth, such as breathing, speaking and eating. Maintaining the appearance of your mouth will also be a high priority.
Surgery
The aim of surgery for mouth cancer is to remove any affected tissue while minimising damage to the rest of the mouth.
If the cancer is advanced, it may be necessary to remove part of your mouth lining and, in some cases, facial skin. This can be replaced using skin taken from elsewhere on your body, such as your forearm or chest (a skin graft).
If your tongue is affected, part of it will have to be removed, called a partial glossectomy.
The tongue may be left to heal on its own – this usually takes 3 to 4 weeks – or it may need to be reconstructed using grafted tissue.
If the cancer has invaded deep into your jawbone, the affected part of the jaw will need to be removed.
Surgeons now use a complex technology called 3D printing to plan the reconstruction so that the replacement bone matches the removed bone almost exactly.
The grafted bone is kept alive by carefully joining tiny arteries and veins under a microscope (microvascular surgery). This increases the length of the operation.
The bone and muscle used for this replacement is usually taken from the lower leg, hip or shoulder blade. Dental implants can often be put into the new bone so that dental bridges can be made to replace lost teeth.
Occasionally, other bones, such as cheekbones, may have to be removed to get rid of the cancer completely.
These can be replaced with bone from other parts of your body, or a specialist dentist can make an extensive denture called an obturator, which holds the cheek out from the inside to give a relatively normal appearance.
During surgery, your surgeon may also remove lymph nodes near the site of the initial tumour. This is often done as a preventative measure in case they contain a small number of cancerous cells that cannot be detected on any scans.
The thought of having reconstructive facial surgery can be worrying. Your surgeon should explain the operation to you in detail and answer any questions you have.
You may also find it helpful to talk to other people who've had the same operation.
Glossectomy
Glossectomy is the name of the surgery used to remove tongue cancers. For smaller cancers, only part of the tongue may need to be removed (partial glossectomy). For larger cancers, a more substantial portion of the tongue may need to be taken out.
Reconstruction of the tongue is often part of the care plan.For example, we frequently bring a skin and subcutaneous tissue from a distant site to rebuild the tongue. Using microsurgical techniques, we connect the tiny blood vessels and nerves of the skin tissue to those in the neck.
Mandibulectomy
A mandibulectomy (also called mandibular resection) involves the removal of part of the jawbone (mandible) when a tumor is very close or attached to the bone. A mandibulectomy is most common for mouth cancers that begin in the lower gums or the floor of the mouth.
The amount of bone that needs to be removed during a mandibulectomy varies according to the location of your tumor.
In some cases, your surgeon may recommend removal of just a rim of the underlying jawbone. This is called a marginal mandibulectomy. No reconstruction of the jawbone is needed, and it does not affect the shape of the jaw.
Other times, your surgeon may recommend that the full thickness of the mandible be removed. This is called a segmental mandibulectomy. Tooth bearing segments of the mandible are usually rebuilt by bringing the part of a distant bone again through a microsurgical technique
Maxillectomy
Maxillectomy is a surgery to remove bones that make up the hard palate (the bony front part of the roof of the mouth) or the nasal sinuses. It is most commonly recommended for mouth cancers that begin in the hard palate or the upper gums.
The space in the roof of the mouth that this operation creates can be addressed with either reconstructive surgery or a custom-fit obturator. The obturators usually work quite satisfactorily in replacing missing upper jaw from both aesthetic and functional standpoints.
Lymph Node Removal During Mouth Cancer Surgery
Mouth cancers often spread to the lymph nodes in the neck first. Removing the lymph nodes in the neck (and other nearby tissue) may be done at the same time as the surgery to remove the mouth cancer. The goal of this procedure is to remove lymph nodes shown to contain, or that are likely to contain, cancer and to reduce the chance that the cancer may return in the future. Lymph node removal is most commonly recommended for cancers that begin in the tongue, the floor of the mouth, or the lower gums.We perform these procedures by preserving normal structures in the neck to leave minimal effects of surgery.
Reconstructive Surgery for Mouth Cancer
Reconstructive surgery for mouth cancer often involves the transplantation of tissue from one area of your body to the affected area of your mouth. This involves a microsurgical approach called free tissue transfer. This is when a plastic surgeon transfers a piece of your own tissue, along with the blood vessels, to the area where the cancer was removed in order to repair the surgical site. Tiny sutures (stitches) are used to connect the small blood vessels of the tissue to the blood vessels in the neck. That allows the transferred tissue to thrive and heal properly